Nano Research

Article Title

Diagnosis of breast cancer by analysis of sialic acid concentrations in human saliva by surface-enhanced Raman spectroscopy of silver nanoparticles


breast cancer, surface-enhanced Raman spectroscopy (SERS), Raman, nanoparticles, sialic acid


ABSTRACT Breast cancer is the most common type of malignant tumor among women and their second leading cause of cancer-related deaths. The most common method for screening and diagnosis is mammography. Nonetheless, two main problems have been identified. First, the dose of radiation received during the test prevents the method from the use on women who are 7 mg·dL–1 is a cutoff for positive test results. Our findings prove the usefulness of this SERS technique as a simple, convenient, and highly sensitive method of quantitative analysis of SA in saliva. The simplicity of this nanotechnological test may help to substantially reduce the mortality among patients with breast cancer by providing women with a simple, noninvasive screening test that can be applied regardless of age or density of breast tissue.

Graphical Abstract


Tsinghua University Press