Article Title

Diagnosis of breast cancer by analysis of sialic acid concentrations in human saliva by surface-enhanced Raman spectroscopy of silver nanoparticles

Authors

Aida Hernández-Arteaga, Coordinación para la Innovación y Aplicación de la Ciencia y la Tecnología (CIACYT), Universidad Autónoma de San Luís Potosí, lvaro Obregón 64, San Luis Potosí, S.L.P. 78000, México
José de Jesús Zermeo Nava, División de Gineco-Obstetricia, Hospital Central Dr. Ignacio Morones Prieto, Ave. Venustiano Carranza 2395, Zona Universitaria, San Luis Potosí, S.L.P. 78290, México
Eleazar Samuel Kolosovas-Machuca, Coordinación para la Innovación y Aplicación de la Ciencia y la Tecnología (CIACYT), Universidad Autónoma de San Luís Potosí, lvaro Obregón 64, San Luis Potosí, S.L.P. 78000, México
J. Jesús Velázquez-Salazar, Department of Physics and Astronomy, University of Texas at San Antonio, San Antonio, TX 78249, USA
Ekaterina Vinogradova, Department of Physics and Astronomy, University of Texas at San Antonio, San Antonio, TX 78249, USA
Miguel José-Yacamán, Coordinación para la Innovación y Aplicación de la Ciencia y la Tecnología (CIACYT), Universidad Autónoma de San Luís Potosí, lvaro Obregón 64, San Luis Potosí, S.L.P. 78000, México Department of Physics and Astronomy, University of Texas at San Antonio, San Antonio, TX 78249, USA
Hugo Ricardo Navarro-Contreras, Coordinación para la Innovación y Aplicación de la Ciencia y la Tecnología (CIACYT), Universidad Autónoma de San Luís Potosí, lvaro Obregón 64, San Luis Potosí, S.L.P. 78000, México

Keywords

breast cancer, surface-enhanced Raman spectroscopy (SERS), Raman, nanoparticles, sialic acid

Abstract

ABSTRACT Breast cancer is the most common type of malignant tumor among women and their second leading cause of cancer-related deaths. The most common method for screening and diagnosis is mammography. Nonetheless, two main problems have been identified. First, the dose of radiation received during the test prevents the method from the use on women who are 7 mg·dL–1 is a cutoff for positive test results. Our findings prove the usefulness of this SERS technique as a simple, convenient, and highly sensitive method of quantitative analysis of SA in saliva. The simplicity of this nanotechnological test may help to substantially reduce the mortality among patients with breast cancer by providing women with a simple, noninvasive screening test that can be applied regardless of age or density of breast tissue.

Graphical Abstract

DOI

https://doi.org/10.1007/s12274-017-1576-5

Publisher

Tsinghua University Press

Recommended Citation

Aida Hernández-Arteaga,José de Jesús Zermeño Nava,Eleazar Samuel Kolosovas-Machuca,J. Jesús Velázquez-Salazar,Ekaterina Vinogradova,Miguel José-Yacamán,Hugo Ricardo Navarro-Contreras, Diagnosis of breast cancer by analysis of sialic acid concentrations in human saliva by surface-enhanced Raman spectroscopy of silver nanoparticles. NanoRes.2017, 10(11): 3662–3670