•  
  •  
 
Nano Research

Article Title

Multifunctional core/satellite polydopamine@Nd3+-sensitized upconversion nanocomposite: A single 808 nm near-infrared light-triggered theranostic platform for in vivo imaging-guided photothermal therapy

Authors

Xing Ding, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS), Changchun 130022, China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, China
Jianhua Liu, State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, China Department of Radiology, the Second Hospital of Jilin University, Changchun 130041, China
Dapeng Liu, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS), Changchun 130022, China
Junqi Li, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS), Changchun 130022, China
Fan Wang, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS), Changchun 130022, China
Leijiao Li, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS), Changchun 130022, China
Yinghui Wang, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS), Changchun 130022, China
Shuyan Song, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS), Changchun 130022, China
Hongjie Zhang, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS), Changchun 130022, China

Keywords

Nd3+-sensitized upconversion nanoparticles, dual-modality imaging, photothermal therapy, multifunctional theranostic platform, biocompatibility

Abstract

ABSTRACT Significant attenuation and overheating, caused by the absorption of the excitation band (980 nm) in water, are the major obstacles in the in vivo application of lanthanide-doped upconversion nanoparticles (UCNPs). Therefore, appropriatelystructured Nd3+-doped UCNPs with 808 nm excitation could be a promising alternative. Herein, we developed core–shell–shell structured Nd3+-sensitized UCNPs as imaging agents, and decorated them onto the surface of polydopamine (PDA) to construct a novel multifunctional core/satellite nanotheranostic (PDA@UCNPs) for in vivo imaging guidance photothermal therapy using single 808 nm laser irradiation. The core–shell–shell structured design enabled outstanding upconversion luminescence properties and strong X-ray attenuation, thereby making the nanocomposites potential candidates for excellent upconversion luminescence/computed tomography dual modal imaging. In addition, the PDA core not only provides high photothermal conversion efficiency and outstanding antitumor effect, but also endows the platform with robust biocompatibility owing to its natural features. Therefore, this multifunctional nanocomposite could be a promising theranostic in future oncotherapy, with high therapeutic effectiveness but low side effects. This study would stimulate interest in designing bioapplication-compatible multifunctional nanocomposites, especially for cancer diagnosis and treatment in vivo.

Graphical Abstract

Publisher

Tsinghua University Press

Share

COinS