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Nano Research

Article Title

In situ synthesis of graphene oxide/gold nanorods theranostic hybrids for efficient tumor computed tomography imaging and photothermal therapy

Authors

Bingmei Sun, School of Materials Science and Engineering, Tongji University, Caoan Road 4800, Shanghai 201804, China The Institute for Translational Nanomedicine, Shanghai East Hospital, The Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai 200120, China
Jinrui Wu, School of Mechanical Engineering, Tongji University, Shanghai 200092, China
Shaobin Cui, The Institute for Translational Nanomedicine, Shanghai East Hospital, The Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai 200120, China
Huanhuan Zhu, The Institute for Translational Nanomedicine, Shanghai East Hospital, The Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai 200120, China
Wei An, School of Mechanical Engineering, Tongji University, Shanghai 200092, China
Qingge Fu, Department of Emergency, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
Chengwei Shao, Radiology Department of Changhai Hosptial, Second Military Medical University, Shanghai 200433, China
Aihua Yao, School of Materials Science and Engineering, Tongji University, Caoan Road 4800, Shanghai 201804, China
Bingdi Chen, The Institute for Translational Nanomedicine, Shanghai East Hospital, The Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai 200120, China
Donglu Shi, The Institute for Translational Nanomedicine, Shanghai East Hospital, The Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai 200120, China Materials Science and Engineering Program, Department of Mechanical and Materials Engineering, College of Engineering and Applied Science, University of Cincinnati, Cincinnati, Ohio 45221-0012, USA

Keywords

graphene oxide/goldnanorods, in situ growth, computed tomographyimaging, photothermal therapy

Abstract

ABSTRACT Graphene oxide/gold nanorod (GO/GNR) nanohybrids were synthesized with a GO- and gold-seed-mediated in situ growth method at room temperature by mixing polystyrene sulfonate (PSS) functionalized GO, secondary growth solution, and gold seeds. Compared with ex situ preparation methods of GO/GNRs or graphene (G)/GNRs, the in situ synthesis of GO/GNRs addressed the issue of the aggregation of the GNRs before their attachment onto the GO. The method is straightforward and environment-friendly. The GO/GNRs showed a remarkable photothermal effect in vitro. The temperature of the GO/GNR nanohybrids increased from 25 to 49.9 °C at a concentration of 50 μg/mL after irradiation with an 808-nm laser (0.4 W/cm2) for 6 min. Additionally, the GO/GNRs exhibited good optical and morphological stability and photothermal properties after six cycles of laser irradiation. Upon injection of the GO/GNRs into xenograft tumors, excellent computed tomography (CT) imaging properties and photothermal effect were obtained. The preclinical CT agent iohexol was combined with the GO/GNRs and further enhanced CT imaging. Therefore, the GO/GNR nanohybrids have great potential for precise CT-image-guided tumor photothermal treatment.

Graphical Abstract

Publisher

Tsinghua University Press

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