"Bioconjugated silica nanoparticles: Development and applications" by Lin Wang, Wenjun Zhao et al.

Article Title

Bioconjugated silica nanoparticles: Development and applications

Authors

Lin Wang, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
Wenjun Zhao, Chinese Academy of Inspection and Quarantine, Huixinli 241, Chaoyang District, Beijing 100029, China Center for Research at the Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200, USA
Weihong Tan, Center for Research at the Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200, USA

Keywords

Nanoscience, nanotechnology, silica nanoparticles, bioanalysis, biomedicine

Abstract

Advanced bioanalysis, including accurate quantitation, has driven the need to understand biology and medicine at the molecular level. Bioconjugated silica nanoparticles have the potential to address this emerging challenge. Particularly intriguing diagnostic and therapeutic applications in cancer and infectious disease as well as uses in gene and drug delivery, have also been found for silica nanoparticles. In this review, we describe the synthesis, bioconjugation, and applications of silica nanoparticles in different bioanalysis formats, such as selective tagging, barcoding, and separation of a wide range of biomedically important targets. Overall, we envisage that further development of these nanoparticles will provide a variety of advanced tools for molecular biology, genomics, proteomics and medicine.