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Journal of Neurorestoratology

Authors

Yunliang Wang, Neurological Center, 960 Hospital of Chinese PLA, Zibo 255300, Shandong, China;Neurological Department, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, Henan, China
Xiaoling Guo, Neurological Department, 981 Hospital of Chinese PLA, Chengde 067000, Hebei, China
Jun Liu, Neurological Department, Civil Aviation Guangzhou Hospital, Guangzhou 510405, Guangdong, China
Zuncheng Zheng, Department of Rehabilitation, Taian Central Hospital, Taian 271000, Shandong, China
Ying Liu, Institute of Neurorestoratology, Third Medical Center of General Hospital of PLA, Beijing 100039, China;Beijing Hongtianji Neuroscience Academy, Beijing 100143, China
Wenyong Gao, Institute of Neurorestoratology, Third Medical Center of General Hospital of PLA, Beijing 100039, China;Beijing Hongtianji Neuroscience Academy, Beijing 100143, China
Juan Xiao, Institute of Neurorestoratology, Third Medical Center of General Hospital of PLA, Beijing 100039, China;Beijing Hongtianji Neuroscience Academy, Beijing 100143, China
Yanqiu Liu, Neurological Center, 960 Hospital of Chinese PLA, Zibo 255300, Shandong, China
Yan Li, Neurological Department, 981 Hospital of Chinese PLA, Chengde 067000, Hebei, China
Manli Tang, Neurological Department, Civil Aviation Guangzhou Hospital, Guangzhou 510405, Guangdong, China
Linlin Wang, Institute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health, School of Public Health, Peking University Health Science Center, Beijing 100191, China
Lin Chen, Department of Neurosurgery, Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine, Beijing 100700, China
Di Chen, Beijing Hongtianji Neuroscience Academy, Beijing 100143, China
Deqiang Guo, E.N.T. Department, 960 Hospital of Chinese PLA, Zibo 255300, Shandong, China
Fei Liu, E.N.T. Department, 960 Hospital of Chinese PLA, Zibo 255300, Shandong, China
Weidong Chen, E.N.T. Department, 981 Hospital of Chinese PLA, Chengde 067000, Hebei, China
Baomin Chan, E.N.T. Department, Civil Aviation Guangzhou Hospital, Guangzhou 510405, Guangdong, China
Bo Zhou, Neurological Department, 981 Hospital of Chinese PLA, Chengde 067000, Hebei, China
Aibing Liu, Institute of Neurorestoratology, Third Medical Center of General Hospital of PLA, Beijing 100039, China
Gengsheng Mao, Institute of Neurorestoratology, Third Medical Center of General Hospital of PLA, Beijing 100039, China

Keywords

olfactory ensheathing cells, Schwann cells, chronic ischemic stroke, cell therapy, randomized control trial

Abstract

Olfactory ensheathing cells (OECs) have shown promising results for patients with neurologic diseases in non-double-blind, placebo control studies. Thirty patients with a unilateral ischemic stroke of more than a year were enrolled in a phase 2, multicenter, randomized, double-blind, and placebo-controlled cell therapy trial with a subsequent 12-month follow-up. The primary therapeutic objective has shown that after 12 months, there were significant differences in National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS) and Barthel Index (BI) assessment scores among the OEC group, Schwann cell group and placebo medium group at one-year follow-up. The second therapeutic objective found that there were significant differences in NIHSS, mRS, and BI assessment scores when comparing the endpoint data with the baseline data in the OEC group. There was neither hypersensitivity reaction nor adverse event. The results of this multicenter, randomized, double-blind, and placebo-controlled study indicate that injecting OECs into the olfactory sub-mucosa have neurorestorative effects, which can improve the quality of life for patients with chronic ischemic strokes without serious side effects.

Publisher

Tsinghua University Press

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