•  
  •  
 
Journal of Neurorestoratology

Authors

Zhao Yang, National Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing 100084, China
Ciliu Zhang, Department of Pediatrics, Xiangya Hospital of Central South University, Changsha 410008, Hunan, China;Hunan Intellectual and Developmental Disabilities Research Center of Children, Changsha 410008, Hunan, China
Zhiyan Wang, National Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing 100084, China
Tungyang Cheng, National Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing 100084, China
Xiaoya Qin, National Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing 100084, China;Precision Medicine and Healthcare Research Center, Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen 518071, China
Jin Deng, National Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing 100084, China
Xi Fang, National Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing 100084, China
Hongwei Hao, National Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing 100084, China
Jing Peng, Department of Pediatrics, Xiangya Hospital of Central South University, Changsha 410008, Hunan, China;Hunan Intellectual and Developmental Disabilities Research Center of Children, Changsha 410008, Hunan, China
Fei Yin, Department of Pediatrics, Xiangya Hospital of Central South University, Changsha 410008, Hunan, China;Hunan Intellectual and Developmental Disabilities Research Center of Children, Changsha 410008, Hunan, China
Luming Li, National Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing 100084, China;Precision Medicine and Healthcare Research Center, Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen 518071, China;Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing 100069, China

Keywords

vagal nerve stimulation, pre-school children, intractable epilepsy, Gesell scale, heart rate variability

Abstract

There is lack of prospective evidence regarding vagal nerve stimulator (VNS) in younger children with intractable epilepsy. Here, we report the outcomes of using VNS in two pre-school patients for pediatric intractable epilepsy (VNS-PIE) study. Medical treatment was ineffective in both the patients, and they underwent VNS implantation. Seizure frequency, score on the Gesell scale, and heart rate variability (HRV) were assessed following VNS therapy. After 6 months VNS treatment, the seizure frequency in the two patients decreased by 50% from that at baseline, based on the records in their epileptic diary. Video electroencephalography (EEG) examinations showed that abnormal fast waves diminished in the background in Patient 1, and captured seizure frequency in Patient 2 remarkably decreased. The adaptability, language, and individual and social interaction on their Gesell scales increased slightly, suggesting that VNS had a positive effect on the development of these two children. Moreover, the changes in the different HRV indices indicated improved cardiac autonomic function. In conclusion, these two cases indicated that VNS may not only be a superior therapy for pre-school children with intractable epilepsy, but also may exert a positive effect on their mental development and cardiac autonomic function.

Publisher

Tsinghua University Press

Share

COinS