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Journal of Neurorestoratology

Authors

Xiaoya Qin, Precision Medicine & Healthcare Research Center, Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen 518071, China;National Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing 100084, China
Sufang Lin, Department of Neurology, Shenzhen Children's Hospital, Shenzhen 518038, Guangdong, China;Epilepsy Center, Shenzhen Children's Hospital, Shenzhen 518038, Guangdong, China
Yuan Yuan, Precision Medicine & Healthcare Research Center, Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen 518071, China;National Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing 100084, China
Jialun Wen, Department of Neurology, Shenzhen Children's Hospital, Shenzhen 518038, Guangdong, China;Epilepsy Center, Shenzhen Children's Hospital, Shenzhen 518038, Guangdong, China
Qian Chen, Department of Neurosurgery, Shenzhen Children's Hospital, Shenzhen 518038, Guangdong, China
Xingguo Lu, Department of Neurology, Shenzhen Children's Hospital, Shenzhen 518038, Guangdong, China;Epilepsy Center, Shenzhen Children's Hospital, Shenzhen 518038, Guangdong, China
Yang Sun, Epilepsy Center, Shenzhen Children's Hospital, Shenzhen 518038, Guangdong, China;Department of Neurosurgery, Shenzhen Children's Hospital, Shenzhen 518038, Guangdong, China
Fangping Wang, Department of Neurology, Shenzhen Children's Hospital, Shenzhen 518038, Guangdong, China
Xiaoqin Tian, Department of Neurology, Shenzhen Children's Hospital, Shenzhen 518038, Guangdong, China
Ning Jiang, Department of Neurology, Shenzhen Children's Hospital, Shenzhen 518038, Guangdong, China
Jianxiang Liao, Department of Neurology, Shenzhen Children's Hospital, Shenzhen 518038, Guangdong, China;Epilepsy Center, Shenzhen Children's Hospital, Shenzhen 518038, Guangdong, China
Luming Li, Precision Medicine & Healthcare Research Center, Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen 518071, China;National Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing 100084, China;IDG/McGovern Institute for Brain Research at Tsinghua University, Beijing 100084, China;Institute of Epilepsy, Beijing Institute for Brain Disorders, Beijing 100093, China

Keywords

vagus nerve stimulation, drug-resistant epilepsy, genetic mutation, EEG brain network

Abstract

Vagus nerve stimulation (VNS) is a neuromodulation therapy increasingly used for treating drug-resistant epilepsy. However, it remains to be determined which patients are best suited for the treatment, and it is difficult to predict the therapeutic effect before the implantation. Mutations in some genes could lead to epilepsy. Here we report two cases of pediatric patients with drug-resistant epilepsy treated by VNS therapy: Patient 1 with ARX mutation achieved good outcomes; Patient 2 with the CDKL5 mutation did not show improvement. Additionally, the therapeutic impact of VNS on brain networks was investigated, hoping to provide some empirical evidence for a better understanding of the mechanism of VNS treatment.

Publisher

Tsinghua University Press

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