spinal cord injury, stem cells, olfactory ensheathing cells, hydrogel, transdifferentiation
As with all tissues of the central nervous system, the low regeneration ability of spinal cord tissue after injury decreases the potential for repair and recovery. Initially, in spinal cord injuries (SCI), often the surgeon can only limit further damage by early surgical decompression. However, with the development of basic science, especially the development of genetic engineering, molecular biology, tissue engineering, and materials science, some promising progress has been made in promoting the repair of central nervous system injuries. For example, transplantation of neural stem cells (NSCs), olfactory ensheathing cells (OECs), and gene- mediated transdifferentiation to repair central nervous system injury. This paper summarizes the progress and prospects of SCI repair with tissue engineering scaffold and cell transdifferentiation from an extensive literatures.
Tsinghua University Press
Changke Ma, Peng Zhang, Yixin Shen. Progress in research into spinal cord injury repair: Tissue engineering scaffolds and cell transdifferentiation. Journal of Neurorestoratology 2019, 07(04): 196-206.