Article Title
Keywords
cerebral small vascular disease, cognitive impairment, neuroimaging markers
Abstract
Cerebral small vessel disease (CSVD) is a pathophysiological process involving small arteries such as cerebellar arteries, arterioles, capillaries, and veinlets. Imaging features vary; they are mainly composed of recent subcortical infarcts, lacunes of presumed vascular origin, white matter hyperintensities (WMHs) of presumed vascular origin, cerebral microbleeds, enlarged perivascular spaces, and global and regional brain atrophy. CSVD is a common cause of vascular cognitive dysfunction, and in its end stage, dementia often develops. CSVD has been a major research hotspot; however, its causes are poorly understood. Neuroimaging markers of CSVD can be used as the basis for etiological analysis. This review highlights the relevance of neuroimaging markers and cognitive impairment, providing a new direction for the early recognition, treatment, and prevention of cognitive dysfunction in small cerebral angiopathy.
Publisher
Tsinghua University Press
Recommended Citation
Lifang Meng, Jianhua Zhao, Junli Liu et al. Cerebral small vessel disease and cognitive impairment. Journal of Neurorestoratology 2019, 07(04): 184-195.
Included in
Biomedical Engineering and Bioengineering Commons, Nervous System Diseases Commons, Neurology Commons, Neurosciences Commons, Neurosurgery Commons