"The Golgi apparatus in neurorestoration" by Jianyang Liu, Jialin He et al.

Article Title

Authors

Jianyang Liu, Department of Neurology, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China
Jialin He, Department of Neurology, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China
Yan Huang, Department of Neurology, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China
Han Xiao, Department of Neurology, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China
Zheng Jiang, Department of Neurology, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China
Zhiping Hu, Department of Neurology, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China

Keywords

Golgi apparatus, neurogenesis, synaptogenesis, angiogenesis, neurodegeneration

Abstract

The central role of the Golgi apparatus in critical cellular processes such as the transport, processing, and sorting of proteins and lipids has placed it at the forefront of cell science. Golgi apparatus dysfunction caused by primary defects within the Golgi or pharmacological and oxidative stress has been implicated in a wide range of neurodegenerative diseases. In addition to participating in disease progression, the Golgi apparatus plays pivotal roles in angiogenesis, neurogenesis, and synaptogenesis, thereby promoting neurological recovery. In this review, we focus on the functions of the Golgi apparatus and its mediated events during neurorestoration.