chronic lower cervical spinal cord injury, functional recovery, nerve segment insert grafting
Objective:The objective of this study was to show that hand functions could be recovered using nerve segment insert grafting in quadriplegic patients with chronic incomplete lower cervical spinal cord injury (CSCI) (C5/6/7/8).Methods:A retrospective analysis was performed in 18 quadriplegic patients (12 male and 6 female patients; mean age, 27 years; age range, 17–55 years) with chronic incomplete lower CSCI who had undergone nerve segment insert grafting from January 2001 to June 2015. Among the 18 patients, the right upper limb was involved in 7, left upper limb in 4, and bilateral upper limbs in 7 patients.Results:The mean follow-up period was 16 months (range, 3 months–3 years), and all patients exhibited obvious relief of limb spasm. Among all patients, 15 patients experienced no obvious spasm attacks and exhibited recovery of living abilities, i.e., recovery of the hand functions of grasping, holding, and pinching, and recovery of pain and temperature sensation in the fingers and palms; furthermore, they were able to steer an ordinary wheelchair independently postoperatively. The remaining three patients exhibited a significant and continuous improvement in hand functions over time, without any significant donor nerve dysfunction.Conclusions:Nerve segment insert grafting is an effective method that helps recover hand functions in quadriplegic patients with chronic incomplete lower CSCI. Moreover, spasticity can be relieved and partial normal innervation can be obtained in the spastic muscles postoperatively.
Tsinghua University Press
Wenbin Ding, Shaocheng Zhang, Dajiang Wu et al. Hand function recovery using nerve segment insert grafting in patients with chronic incomplete lower cervical spinal cord injury: a preliminary clinical report. Journal of Neurorestoratology 2019, 7(3): 129-135.