"Synthesis of carbon nanotubes loaded hydroxyapatite: Potential for con" by Lisa COSTANTINI, Nikolaos BOUROPOULOS et al.

Article Title

Synthesis of carbon nanotubes loaded hydroxyapatite: Potential for controlled drug release from bone implants

Authors

Lisa COSTANTINI, School of Pharmacy and Biomedical Science, University of Portsmouth, St Michael’s Building, White Swan Road, Portsmouth, UK
Nikolaos BOUROPOULOS, Department of Materials Science, University of Patras, 26504 Rio, Patras, Greece Foundation for Research and Technology, Hellas–Institute of Chemical Engineering and High Temperature Chemical Processes—FORTH/ICEHT, P.O. Box 1414, GR 26504 Patras, Greece
Dimitrios G. FATOUROS, Department of Pharmaceutical Technology, School of Pharmacy, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece
Ioanna KONTOPOULOU, Department of Materials Science, University of Patras, 26504 Rio, Patras, Greece
Marta ROLDO, School of Pharmacy and Biomedical Science, University of Portsmouth, St Michael’s Building, White Swan Road, Portsmouth, UK

Keywords

carbon nanotubes (CNTs), hydroxyapatite (HA) composites, bone regeneration, chitosan

Abstract

Carbon nanotubes (CNTs) can support the building of flexible and porous scaffolds for bone regeneration. Various studies have looked at the mixing of CNTs with hydroxyapaptite for the formulation of bone implants. In the present work, we report the one step preparation and characterisation of chitosan/hydroxyapatite/CNTs composite materials obtained by wet precipitation of hydroxyapatite (HA) in the presence of chitosan or its amphiphilic derivative N-octyl-O-sulphate chitosan and CNTs. The in situ precipitation of HA assured inclusion of the polysaccharide and the CNTs in the HA structure and provided materials with the ability to control the release of different model drugs.

DOI

https://doi.org/10.1007/s40145-016-0195-z

Publisher

Tsinghua University Press

Recommended Citation

Lisa COSTANTINI, Nikolaos BOUROPOULOS, Dimitrios G. FATOUROS et al. Synthesis of carbon nanotubes loaded hydroxyapatite: Potential for controlled drug release from bone implants. Journal of Advanced Ceramics 2016, 5(3): 232-243.

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