carbon, core–shell structure, gadolinia particles, fluorescence, magnetic resonance imaging (MRI) contrast agent
In the present study, we report a fabrication of dual-mode carbon coated gadolinia C@Gd2O3 particles by a facile hydrothermal synthesis method without using any organic solvents. The prepared C@Gd2O3 particles have a core–shell structure and a narrow size distribution in the range of 261±27 nm. The fluorescent properties of the prepared C@Gd2O3 particles were accessed by a room-temperature photoluminescence study, while the longitudinal relaxivity (r1) was examined by using a clinical 1.5 T MRI scanner. A murine fibroblast L-929 cell line was used to examine the cytotoxicity and capability of the prepared C@Gd2O3 particles for the fluorescent labeling. The obtained results show that the prepared C@Gd2O3 particles could be used as a dual-mode contrast agent for magnetic resonance and fluorescence imaging.
Tsinghua University Press
Timur Sh. ATABAEV, Jong Ho LEE, Dong-Wook HAN et al. Fabrication of carbon coated gadolinia particles for dual-mode magnetic resonance and fluorescence imaging. Journal of Advanced Ceramics 2015, 4(2): 118-122.