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Brain Science Advances

Authors

Cheng Wang, The Innovation Institute for Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China
Liangxing Zhou, The Innovation Institute for Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China
Mei Mo, Experimental Centre, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China
Xianglin Kong, Experimental Centre, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China
Zhengbin Chai, The Innovation Institute for Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China
Lei Deng, The Innovation Institute for Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China
Junli Zhang, The Innovation Institute for Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China
Kuan Cao, The Innovation Institute for Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China
Chuanfei Wei, The Institute for Tissue Engineering and Regenerative Medicine, Stem Cell and Regenerative Medicine Laboratory, Liaocheng University/Liaocheng People’s Hospital, Liaocheng 252000, Shandong, China
Li Xu, The Institute for Tissue Engineering and Regenerative Medicine, Stem Cell and Regenerative Medicine Laboratory, Liaocheng University/Liaocheng People’s Hospital, Liaocheng 252000, Shandong, China
Juanli Chen, The Institute for Tissue Engineering and Regenerative Medicine, Stem Cell and Regenerative Medicine Laboratory, Liaocheng University/Liaocheng People’s Hospital, Liaocheng 252000, Shandong, China
Fabin Han, The Innovation Institute for Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China; The Institute for Tissue Engineering and Regenerative Medicine, Stem Cell and Regenerative Medicine Laboratory, Liaocheng University/Liaocheng People’s Hospital, Liaocheng 252000, Shandong, China

Keywords

Lycium barbarum polysaccharide, oxidative stress, neuroprotection, neurodegenerative disease, ischemic brain injury, neural stem cell

Abstract

Lycium barbarum polysaccharides (LBPs) are the major polysaccharides extracted from L. barbarum, which is used in traditional Chinese medicine (TCM) for treating diseases. Studies have shown that LBPs have important biological activities, such as antioxidation, anti-aging, neuroprotection, immune regulation. LBPs inhibit oxidative stress, improve neurodegeneration and stroke-induced neural injury, increase proliferation and differentiation of neural stem cell, and promote neural regeneration. Here we have reviewed latest advances in the biomedical activities of LBPs and improved methods for the isolation, extraction, and purification of LBPs. Then, new discoveries to decrease oxidative stress and cellular apoptosis, inhibit aging progress, and improve neural repair in neurodegeneration and ischemic brain injury have been discussed in detail through in vitro cell culture and in vivo animal studies. Importantly, the molecular mechanisms of LBPs in playing neuroprotective roles are further explored. Lastly, we discuss the perspective of LBPs as biomedical compounds in TCM and modern medicine and provide the experimental and theoretical evidence to use LBPs for the treatment of aging-related neurological diseases and stroke-induced neural injuries.

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