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Brain Science Advances

Keywords

moderate TBI, attention, fatigue, resting state, electroencephalography, power spectral density, Higuchi fractal dimension, Hjorth complexity, envelope frequency

Abstract

Purpose: Even in years after recovery from moderate traumatic brain injury (moderate TBI), patients complain about residual cognitive impairment and fatigue. We hypothesized that non-linear and linear resting-state electroencephalography (rsEEG) features might also reflect neural underpinnings of these deficits. Methods: We analyzed a 10-minute rsEEG in 77 moderate TBI-survivors and 151 healthy volunteers after cognitive and psychological assessment. The rsEEG analysis included linear measures, such as power spectral density and peak alpha frequency, and non-linear parameters such as Higuchi fractal dimension, envelope frequency, and Hjorth complexity. Results: The patients with moderate TBI had higher scores for fatigue and sleepiness and lower scores for mood and life satisfaction than controls. The behavioral test for directed attention showed a smaller and non-significant between-group difference. In rsEEG patterns, moderate TBI-group had significantly higher delta- and theta-rhythm power, which correlated with higher sleepiness and fatigue scores. The higher beta and lower alpha power were associated with a higher attention level in moderate TBI patients. Non-linear rsEEG features were significantly higher in moderate TBI patients than in healthy controls but correlated with sleepiness and fatigue scores in both controls and patients. Conclusion: The rsEEG patterns may reflect compensatory processes supporting directed attention and residual effect of moderate TBI causing subjective fatigue in patients even after full physiological recovery.

Publisher

Tsinghua University Press

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