"Genome-wide studies of time of day in the brain: Design and analysis" by Gang Wu, Marc D. Ruben et al.

Home > BRAIN-SCIENCE-ADVANCES > Vol. 6 (2020) > No. 2

Article Title

Genome-wide studies of time of day in the brain: Design and analysis

Authors

Gang Wu, Divisions of Human Genetics and Immunobiology, Center for Chronobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 240 Albert Sabin Way, Cincinnati, OH 45229, U.S.A.
Marc D. Ruben, Divisions of Human Genetics and Immunobiology, Center for Chronobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 240 Albert Sabin Way, Cincinnati, OH 45229, U.S.A.
Yinyeng Lee, Divisions of Human Genetics and Immunobiology, Center for Chronobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 240 Albert Sabin Way, Cincinnati, OH 45229, U.S.A.
Jiajia Li, Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63310, U.S.A.
Michael E. Hughes, Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63310, U.S.A.
John B. Hogenesch, Divisions of Human Genetics and Immunobiology, Center for Chronobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 240 Albert Sabin Way, Cincinnati, OH 45229, U.S.A.

Keywords

circadian, transcriptome, rhythmic analysis, brain

Abstract

Transcriptome profiling at different times of day is powerful for studying circadian regulation in model organisms and humans. To date, 24 h profiles from many tissue types suggest that about half of all genes are circadian-expressed somewhere in the body. However, few of these studies focused on the brain. Thus, despite known links between circadian disruption and neurological disease, we have virtually no mechanistic understanding. In the coming decade, we expect more genome-wide studies of time of day in different brain diseases, regions, and cell types. We expect just as many different approaches to the design and analysis of these studies. This review considers key principles of circadian tran scriptomics, with the goal of maximizing utility and reproducibility of future studies in the nervous system.

DOI

https://doi.org/10.26599/BSA.2020.9050005

Publisher

Tsinghua University Press

Recommended Citation

Gang Wu, Marc D. Ruben, Yinyeng Lee et al. Genome-wide studies of time of day in the brain: Design and analysis. Brain Science Advances 2020, 6(2): 92-105.

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