"Individual differences of maladaptive brain changes in migraine and th" by Karen M. von Deneen, Ling Zhao et al.

Article Title

Individual differences of maladaptive brain changes in migraine and their relationship with differential effectiveness of treatments

Authors

Karen M. von Deneen, Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an 710126, Shaanxi, China Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, Xi'an 710126, Shaanxi, China
Ling Zhao, Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China
Jixin Liu, Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an 710126, Shaanxi, China Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, Xi'an 710126, Shaanxi, China

Keywords

migraine, nonpharmacological treatment, individual differences, neuroimaging

Abstract

Migraine is a difficult disorder to identify with regard to its pathophysiological mechanisms, and its treatment has been primarily difficult owing to interindividual differences. Substantial rates of nonresponsiveness to medications are common, making migraine treatment complicated. In this review, we systematically analyzed recent studies concerning neuroimaging findings regarding the neurophysiology of migraine. We linked the current imaging research with anecdotal evidence from interindividual factors such as duration and pain intensity of migraine, age, gender, hormonal interplay, and genetics. These factors suggested the use of nonpharmacological therapies such as transcranial magnetic stimulation, transcranial direct current stimulation, and placebo therapy for the treatment of migraine. Finally, we discussed how interindividual differences are related to such nondrug treatments.

DOI

https://doi.org/10.26599/BSA.2019.9050021

Publisher

Tsinghua University Press

Recommended Citation

Karen M. von Deneen, Ling Zhao, Jixin Liu. Individual differences of maladaptive brain changes in migraine and their relationship with differential effectiveness of treatments. Brain Science Advances 2019, 05(04): 239-255.

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