Brain Science Advances


biomimetic bone, skull defect, cranioplasty, complications


The aim of the current study was to investigate the operation skills and complications associated with skull defect repair using biomimetic bone (nano-hap/collagen composites). Clinical data from 45 patients with skull defects who underwent cranioplasty with biomimetic bone from January 2014 to January 2017 were retrospectively analyzed. All patients participated in follow-up visits from 8 months to 3 years postoperatively. Cranioplasties were successful in all 45 patients, but 17 patients (20 cases) presented various complications, including subcutaneous hydrops (14 cases), biomimetic bone fixation loosening (4 cases), wound indolence (1 case), and biomimetic bone fragmentation (1 case). Cranioplasty complications in surgeries using biomimetic bone are more common in children than in adults. Understanding the physicochemical properties of biomimetic bone and the normal developmental process in children, as well as mastering the appropriate surgical skills and implementing the effective preventive measures are all ways to reduce and control the incidence of complications associated with biomimetic bone cranioplasty.


Tsinghua University Press