
Keywords
synaptic plasticity, spine, axonal bouton, sensory deprivation, learning, neurological disease, multi-synaptic bouton, multi-synaptic spine
Abstract
Synaptic plasticity is widely believed to be the cellular basis of learning and memory. It is influenced by various factors including development, sensory experiences, and brain disorders. Long-term synaptic plasticity is accompanied by protein synthesis and trafficking, leading to structural changes of the synapse. In this review, we focus on the synaptic structural plasticity, which has mainly been studied with in vivo two-photon laser scanning microscopy. We also discuss how a special type of synapses, the multi-contact synapses (including those formed by multi-synaptic boutons and multi-synaptic spines), are associated with experience and learning.
Publisher
Tsinghua University Press
Recommended Citation
Yang Yang, Ju Lu, Yi Zuo. Changes of synaptic structures associated with learning, memory and diseases. Brain Science Advances 2018, 04(02): 99-117.
Included in
Biomedical Engineering and Bioengineering Commons, Nervous System Diseases Commons, Neurology Commons, Neuroscience and Neurobiology Commons, Neurosciences Commons, Neurosurgery Commons