"Genetically encoded neural activity indicators" by Fang Luo, Yin Wei et al.

Home > BRAIN-SCIENCE-ADVANCES > Vol. 4 (2018) > No. 1

Article Title

Genetically encoded neural activity indicators

Authors

Fang Luo, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China
Yin Wei, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China
Ziyue Wang, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China
Minmin Luo, National Institute of Biological Sciences, Beijing 102206, China
Ji Hu, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China

Keywords

calcium imaging, neural activity, membrane potential probe, neurotransmitter reporter

Abstract

Recent years have witnessed the fascinating development of imaging approaches to studying neural activities; this progress has been based on an inﬂux of ideas and methods from molecular biology and optical engineering. Here we review the design and application of genetically encoded indicators for calcium ions, membrane potential and neurotransmitters. We also summarize common strategies for the design and optimization of genetically encoded neural activity indicators.